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KMID : 1149220030110020147
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Korean Journal of Oriental Medical Prescription
2003 Volume.11 No. 2 p.147 ~ p.158
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Effect of Each Constituent-Herb of Sagoonja-Tang on the Change of Corticosterone Level induced by Heat Stress in Mice
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Jo Yong-Kook
Lee Tae-Hee
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Abstract
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This study aimed to investigate the effect of each constituent-herb of Sagoonja-Tang on the plasma corticosterone level in mice exposed to heat stress. Each formula(0.5g/kg, 1.0g/kg) was injected intragastrically to mice exposed to forced hot water swimming(42, 3min) before measuring the change of plasma corticosterone level of mice. The results were as follows: 1. At 15 minutes after the heat stress for 3 minutes the most significant increase of corticosterone level was shown. 2. Ginseng group didn’t show significant changes. 3. Atractylodis group showed significant decrease at 0.5g/kg dose(P<0.05). But it showed slightly increase at 1.0g/kg dose. 4. Poria group didn’t show significant changes. 5. Glycyrrhizae group showed slightly increase, but insignificant. These data revealed that Atractylodis macrocephalae Rhizoma might have the anti-stress effect through the control of plasma corticosterone level in mice exposed to heat stress.
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KEYWORD
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Sagoonja-Tang, plasma corticosterone level, heat stress
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